Information Drug 성분

1. 알약은 40°C 이하에 보관하고 15–30°C에서의 보관이 적절함

약리
‘Torsemide, like furosemide inhibits sodium and chloride reabsorption in the ascending loop of Henle via interference with the chloride-binding site of the 1Na+, 1K+, 2Cl- cotransport system.
Torsemide increases renal excretion of water, sodium, potassium, chloride, calcium, magnesium, hydrogen, ammonium, and bicarbonate. In dogs, excretion of potassium is affected much less so than is sodium (20:1); this is approximately twice the ratio of Na:K excreted than with furosemide. In cats, torsemide’s effects on potassium excretion appear to be similar to that of furosemide. In dogs, torsemide appears to have differing effects on aldosterone than furosemide. When compared to furosemide, torsemide increases plasma aldosterone levels and inhibits the amount of receptor-bound aldosterone, however, additional research ‘must be performed to determine the clinical significance of these effects.’

약동학
‘Limited information is available. Oral bioavailability has been reported to be between 80–100% in dogs and cats. Elimination half-life in dogs is about 8 hours which is longer than furosemide. In dogs, diuretic activity begins within one hour of dosing, peaks at about 2 hours and persists for approximately 12 hours.
In cats, peak diuresis occurs about 4 hours post-dose and persists for 12 hours.’